Table 1.
Hippo Pathway Components in Drosophila and Human
| Drosophila | Human | Conserved Domains and Motifs |
|---|---|---|
| The Core Pathway | ||
| Hippo | Mst1-2 | Ste20 Ser/Thr kinase and SARAH domains |
| Salvador | Sav1/WW45 | WW and SARAH domain |
| Warts | Lats1-2 | NDR Ser/Thr kinase domain, PPXY motif |
| Mats | MOBKL1A-B | Mob1/phocein domain |
| Yorkie | YAP, TAZ | WW and TEAD-binding domains |
| Scalloped | TEAD1-4 | TEA/ATTS and Yki/YAP- binding domains |
| Upstream Apical Complex | ||
| Kibra | KIBRA/WWC1,WWC2 | WW and C2 domains |
| Expanded | FRMD6/Ex1,FRMD1/Ex2 | FERM domain |
| Merlin | NF2/Merlin | FERM domain |
| Fat Effectors and Regulators | ||
| Fat | Fat4/Fat-j | EGF-like, Laminin G and Cadherin repeat domains |
| Dachsous | Dchs1-2 | Cadherin repeat domain |
| Four-jointed | Fjx1 | Golgi Ser/Thr kinase |
| Dachs | ? | Myosin motor domain |
| Discs overgrown | CK1δ, CK1ε | Ser/Thr kinase domain |
| Approximated | ZDHHC14 | DHHC zinc finger domain |
| Lowfat | Lix1, Lix1L | unknown conserved domain |
| Apical-Basal Polarity | ||
| Crumbs | Crb1-3 | EGF-like and Laminin G domains, PDZ- and FERM-binding motifs |
| Lgl | Lgl1-2 | LLGL2 domain |
| aPKC | aPKCλ, aPKCζ | PKC kinase, PB1 and C1 domains |
| Other Modulators | ||
| dRASSF | RASSF1-6 | Ras association and SARAH domains |
| dSTRIPAK PP2A | STRIPAK PP2A | PP2A Ser/Thr phosphatase complex |
| dJuba | Ajuba, LIMD1, WTIP | LIM domain |