TABLE 1.

Prices of Genetic Tests for the Five most Commonly Tested Hearing Loss Genes

Gene Name	Type of hearing loss	Prevalen ce in affected	Patent holder	Type of Test	No of providersa		Price of Test ($)b
					NonPr ofit	For Profit	NonPr ofit	For Profit
GJB2	Non syndromic	>50%i	Institut Pasteur US 5998147 US 6485908	Full sequence Analysis	181		472.35c Athena (362–818) Preventiond Diagnostics	575 290
GJB6	Non syndromic	7–16%j	N/A	Deletion Analysis	61		300.25e 295 (161–534)
SLC26A4	Syndromic	4–10%k	N/A	Full sequence Analysis	60		1686f N/A (1100–2507)
MTRNR1	Mitochondrial Non syndromic	<1%i	Cedars-Sinai US 5506101	Targeted mutation	82		210g h (150–285)	248 365
MTTS1	Mitochondrial Non syndromic	<1%i	N/A	Targeted mutation	40		238 N/A (150–285)

^aProviders for specific test type identified from Genetests (see http://www.genetests.org) are current as of January 2009.

^bList prices of tests obtained from phone survey March 2007 or test laboratory web site

^cAverage list price for 14 out of 17 providers offering full sequence analysis

^dPrices of 2 separate for-profit providers in 2008. Preventions Diagnostics is no longer listed on GeneTests as of January 2009.

^eAverage list price for 4 out of 7 providers

^fAverage list price for 4 out of 6 providers, not including NIH which offers testing free of charge to research participants

^gAverage list price for 6 out of 8 providers

^hPrices of 2 separate for-profit providers

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