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. 2011 Feb 1;91(2):289–299. doi: 10.1093/cvr/cvr037

Figure 3.

Figure 3

Cardiac morphologies in E16.5 Nkx2-5 knockout embryos. (A–P) HE-stained serial tissue sections of E16.5 flox/flox and flox/flox/Cre embryos. (A and B) four-chamber heart, VSD in flox/flox/Cre embryo is marked with *; (C and D) left ventricles; (E and F) endocardial cushion and inter-ventricular septum; (G and H) four-chamber heart posterior/dorsal of the sections (A and B) including inferior vena cava connection to right atrium. Additional VSD in flox/flox/Cre (marked with *). (I and J) right ventricle to pulmonary trunk; (K and L) pulmonary valve leaflets; (M and N) left ventricular outflow; (O and P) aortic valve leaflets. Bars = 200 µm. AO, aorta; IVE, inferior vena cava; LSV, left superior vena cava; PA, pulmonary artery; PV, pulmonary vein; SVC, superior vena cava.