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. Author manuscript; available in PMC: 2012 Apr 20.
Published in final edited form as: Chem Phys Lett. 2011 Apr 20;506(4-6):135–138. doi: 10.1016/j.cplett.2011.03.048

Figure 2.

Figure 2

Transition state structures of COMT show Trp143 forming cation-π interaction exclusively in the meta conformation. Residues coordinated to Mg2+ removed for clarity. (a) Meta-methylation. (b) Para-methylation.