. Author manuscript; available in PMC: 2011 Jun 28.

Published in final edited form as: J Med Chem. 2008 Mar 25;51(8):2561–2570. doi: 10.1021/jm701499n

Table 1.

Synthetic yields and antiproliferative activity of pyrano-[3,2-c]-pyridones.

		synthesis	cell viability^a

analogue	Ar	% yield	GI₅₀, μM
8		83	0.33 ± 0.06
9		87	0.58 ± 0.14
10		88	1.1 ± 0.8
11		75	2.7 ± 1.1
12		83	3.5 ± 1.3
13		84	6.4 ± 1.1
14		97	6.5 ± 1.3
15		98	18.3 ± 2.9
16		97	43.3 ± 5.1
17		81	> 100
18		97	35.0 ± 21.8
19		87	> 100
20		80	22.7 ± 6.4

Concentration required to reduce the viability of HeLa cells by 50% after 48 h of treatment with indicated compounds relative to DMSO control ± SD from three independent experiments, each performed in 4 replicates, determined by MTT assay.