Table 1.

Percent of WNV-infected hamsters exhibiting successful performance in a spatial memory probe test at day 32 treated. Hamsters were treatedi.p. with the vehicle (saline) or with MGAWN1 at 4.5 days after s.c.viral challenge. The criterion for a successful probe trial was that the hamster spent more time in the target (training) quadrant than in any other quadrant as illustrated in Figure 5.

Time of spatial memory probe trial	WNV-infected, saline-treated	WNV-infected, MGAWN1-treated
Pre-infection	100% (9/9)	100% (13/13)
32 days post-infection	56% (5/9)##	92% (12/13)*

^*P ≤ 0.05 compared to the 32-day probe trial of WNV-infected, saline-treated hamsters

^##P ≤ 0.01 compared to the same animals during the pre-infected probe trial. For statistical analysis, thetwo-sided Chi square test (Prism 5 for Mac OS X, GraphPad Software, Inc) of whether animals spent more time in the target quadrant than any other quadrant was used.