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. Author manuscript; available in PMC: 2011 Jun 28.
Published in final edited form as: Nat Protoc. 2010 Jan 7;5(1):93–121. doi: 10.1038/nprot.2009.203

Table 4.

General error modes in metabolic networks.

Error mode Action
Wrong reaction constraints. Check reaction constraints if they are applied correctly.
Missing transport reactions. Add transport reactions.
Missing exchange reactions. Add exchange reactions.
Cofactor cannot be consumed or produced. Follow Figure 13.
Shuttling of compounds across compartment. Adjust reversibility of transport reactions.