Table 1.
Demographic and Haematological Characteristics of the Sickle Cell Anaemia Patients
| SCA Patients | ||||
|---|---|---|---|---|
| Parameter | Control | Total | Steady | Unsteady |
| No. of cases | 22 | 55 | 31 | 24 |
| Sex, Male/Female | 10/12 | 25/30 | 16/15 | 9/15 |
| Age, yr | 13.0 ± 1.5 | 15.3 ± 1.1 | 17.1 ± 1.6* | 13.2 ± 1.1 |
| aHbF, % | 1.3 ± 0.06 | 3.8 ± 0.2** | 4.2 ± 0.2* | 3.3 ± 0.2 |
| Hb, g/dL | 11.9 ± 0.2 | 8.3 ± 0.2** | 8.9 ± 0.2* | 7.4 ± 0.3 |
| PCV, % | 35.2 ± 0.5 | 25.5 ± 0.5** | 27.3 ± 0.5* | 23.2 ± 0.7 |
| RC, % | 1.7 ± 0.1 | 5.8 ± 0.3** | 6.3 ± 0.4* | 5.3 ± 0.6 |
| % ICI | ND | 6.7 ± 0.3 | 5.3 ± 0.3* | 8.4 ± 0.4 |
| MCHC, g/dL | 34.0 ± 0.5 | 32.4 ± 0.2** | 32.8 ± 0.3* | 31.7 ± 0.2 |
| MCH, pg | 27.4 ± 0.5 | 23.9 ± 0.4** | 25.0 ± 0.4* | 22.6 ± 0.6 |
| MCHC < 31 g/dL, n(%) | 0(0) | 10 (18.2) | 3 (9.7)* | 7 (29.2) |
| MCH < 25 pg, n(%) | 3 (13.6) | 35 (63.6)** | 16 (51.6)* | 19 (79.2) |
| ESR, mm/Hr | 14.4 ± 3.5 | 35.1 ± 1.0** | 25.7 ± 1.1* | 38.4 ± 1.3 |
| WBC, cells/uL × 103 | 6.1 ± 0.2 | 11.7 ± 0.1** | 11.4 ± 0.2* | 12.1 ± 0.1 |
| Neutrophils, cells/uL × 103 | 3.4 ± 0.1 | 7.6 ± 0.1** | 7.2 ± 0.2* | 8.1 ± 0.2 |
| Lymphocytes, cells/uL × 103 | 2.0 ± 0.09 | 2.6 ± 0.1** | 2.6 ± 0.1 | 2.4 ± 0.1 |
| Monocytes, cells/uL × 103 | 0.5 ± 0.04 | 1.0 ± 0.06** | 0.9 ± 0.08 | 1.2 ± 0.09 |
| Eosinophils, cells/uL × 103 | 0.2 ± 0.02 | 0.4 ± 0.03** | 0.5 ± 0.04* | 0.3 ± 0.04 |
| Basophils, cells/uL × 103 | 0.08 ± 0.01 | 0.2 ± 0.02 | 0.1 ± 0.02 | 0.2 ± 0.04 |
| Platelet count, cells/uL × 103 | 241.8 ± 11.6 | 432.8 ± 82.6** | 438.7 ± 11.1* | 371.5 ± 16.2 |
| RBC count, cells/uL × 106 | 4.4 ± 0.07 | 3.5 ± 0.05** | 3.6 ± 0.04* | 3.3 ± 0.07 |
Data are expressed as mean ± SEM or number (%). aHbF was evaluated in 10 control subjects. *P < 0.05 (Steady vs. Unsteady SCA patients); **P < 0.05 (Total SCA patients vs. Control) by Student's t-test or Chi-Square (χ2) analysis; P < 0.05 was considered to be significant.