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. 2011 Jun 28;6(6):e21494. doi: 10.1371/journal.pone.0021494

Figure 3. Expression levels of in vitro stromal markers sorted by tumor stage or by individual cases.

Figure 3

Lysates obtained from fibroblasts cultured in 3D conditions were subjected to Western Blot analyses. Samples were sorted by tissue type (normal kidney and primary or secondary tumors) and by tumor stage. Panels A-D show the optical densities (O.D.) of the corresponding stromal markers relative to GAPDH. Each dot represents a single cell line. Median values as well 25 and 75 percentiles are shown. Note the variations of expression in tumor, with respect to normal, tissues as well as between early (I) and late (III and IV) stages. Sample distribution demonstrates a high level of variation. See Table S3 for details. Panels E-H correspond to median values and errors calculated for lysates obtained from 3D cultures of fibroblasts harvested from both normal and primary tumors sorted by the individual cases.