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. 2011 May 26;12:211. doi: 10.1186/1471-2105-12-211

Table 1.

True and estimated QTL effects for the simulated data with main and epistatic effects.

Markersa Position Trueb EBLASSOc EBc
(i, j) (cM, cM) β(h2) Inline graphic Inline graphic
(11,11) (50,50) 4.47(0.0975) 4.5801(0.1612) 4.8593(0.2075)
(26,26) (125,125) 3.16(0.0524) 3.0768(0.1576) 3.3221(0.2035)
(42,42) (205,205) -2.24(0.0250) -2.3169(0.1796) -2.2769(0.2262)
(48,48) (235,235) -1.58(0.0128) -1.3171(0.1720) -1.3634(0.2205)
(72,72) (355,355) 2.24(0.0247) - 1.6537(0.4277)
(73,73) (360,360) 3.16(0.0506) 5.1247(0.1555) 3.8771(0.4219)
(123,123) (610,610) 1.10(0.0062) - 1.5168(0.2432)
(127,127) (630,630) -1.10(0.0063) - -1.1834(0.2460)
(161,161) (800,800) 0.77(0.0030) - -
(181,181) (900,900) 1.73(0.0152) - -
(182,182) (905,905) 3.81(0.0725) 5.6744(0.2400) 5.5127(0.2894)
(185,185) (920,920) 2.25(0.0263) 1.7123(0.2327) 1.7070(0.2858)
(221,221) (1100,1100) -1.30(0.0088) -1.4276(0.1506) -1.0867(0.1956)d
(243,243) (1210,1210) -1.00(0.0051) -0.8603(0.1486) -
(262,262) (1305,1305) -2.24(0.0245) -2.2539(0.1826) -1.6078(0.2417)
(268,268) (1335,1335) 1.58(0.0120) 2.4264(0.2040) 2.1736(0.2509)
(270,270) (1345,1345) 1.00(0.0049) - -
(274,274) (1365,1365) -1.73(0.0147) -1.4114(0.1800) -1.4935(0.2254)
(361,361) (1800,1800) 0.71(0.0026) 0.7856(0.1457) 0.6520(0.1859)d
(461,461) (2300,2300) 0.89(0.0040) - -
(5,6) (20,25) 2.24(0.0230) 1.7839(0.1654) 1.5752(0.2886)
(6,39) (25,190) 2.25(0.0128) 1.9691(0.2168) -
(42,220) (205,1095) 4.47(0.0511) 4.3836(0.2198) 4.6414(0.3394)
(75,431) (370,2150) 0.77(0.0014) 1.1360(0.2124)d -
(81,200) (400,995) -2.24(0.0128) -2.4190(0.2460) -
(82,193) (405,960) 1.58(0.0063) 1.6345(0.2442) -
(87,164) (430,815) 3.16(0.0235) 2.9263(0.2254) 1.7059(0.3319)d
(87,322) (430,1605) 3.81(0.0342) 4.1019(0.2274) 3.7040(0.3632)
(92,395) (455,1970) 1.73(0.0081) 1.5714(0.2065)d -
(104,328) (515,1635) 1.00(0.0024) 0.8081(0.1979)d -
(118,278) (585,1385) -2.24(0.0120) -2.0796(0.2221) -2.2590(0.3460)
(150,269) (745,1340) 1.10(0.0028) 1.0740(0.2142) -
(237,313) (1180,1560) 0.71(0.0014) - -
(246,470) (1225,2345) -1.10(0.0032) -1.2381(0.2114)d -
(323,464) (1610,2315) 0.89(0.0020) - -
(328,404) (1635,2015) -1.73(0.0079) -2.3036(0.2123) -1.9428(0.3330)
(342,420) (1705,2095) -1.30(0.0041) -1.3886(0.2121)d -
(344,407) (1715,2030) -1.00(0.0025) - -
(373,400) (1860,1995) -1.58(0.0070) -1.4732(0.2028) -
(431,439) (2150,2190) 3.16(0.0278) 2.6700(0.2121) 2.2454(0.3366)d

μ 100 100.70 100.59
Inline graphic 10 11.76 0.25
CPU time 3.4 mins 249 hrs

aWhen i = j, the QTL is a main effect; otherwise, it is an epistatic effect.

bThe true value of a QTL effect is denoted by β and the proportion of variance contributed by the QTL is denoted by h2.

cThe estimated QTL effect is denoted by Inline graphic and the standard error is denoted by Inline graphic. The EBLASSO algorithm used hyperparameters a = b = 0.1 and the EB algorithm used hyperparameters τ = -1 and ω = 0.001.

dThe estimated QTL effect was obtained from a neighboring marker (≤ 20 cM away) rather than from the maker with the true effect.