Table 4.

A summary of treatment options for Henoch-Schonlein Purpura

Medication	Indication
Acetaminophen, NSAID	Mild eruption, arthritis
Colchicine	Severe or recurrent skin disease
Oral glucocorticoids	Severe eruption, cutaneous edema, severe colicky abdominal pain, scrotal and testicular involvement
Parenteral glucocorticoids	Same as oral; unable to tolerate oral medications
High dose parenteral pulse glucocorticoid	Nephrotic range proteinuria
High dose IV pulse glucocorticoids combined with other forms of immunosuppression (such as cyclophosphamide)	Rapidly progressive glomerulonephritis Hemorrhagic involvement of lungs or brain
Plasmapheresis and/or IGIV	Refractory to combination therapy Massive hemorrhage in gastrointestinal or other organs

IV = intravenous; IGIV = intravenous immunoglobulin