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. 2011 Jun 28;6(6):e21683. doi: 10.1371/journal.pone.0021683

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Gao, Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Based on gene ontology, genes can be assigned 3 GO domains, molecular function, biological process and cellular component, which are independent of each other. (A) Essential enzymes have higher proportion of 3-GO-domain and lower proportion of 1&2-GO-domain containing genes. (B) Percentages of 1&2-GO-domain and (C) 3-GO-domain containing genes in essential and non-essential enzymes.