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. 2011 Jun 28;6(6):e21683. doi: 10.1371/journal.pone.0021683

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Gao, Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Part of the pyrimidine metabolism map is shown. The DAVID database was used to identify pathways in which essential genes are enriched, using E. coli as an example. Red rectangles denote reactions involving essential genes; filled yellow and blue boxes represent EC 2.7.7 (nucleotidyltransferase) and EC 2.7.4 (phosphotransferase), respectively.