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. 2011 Jun 28;6(6):e21707. doi: 10.1371/journal.pone.0021707

Figure 5. PDGF-BB induces down regulation of ZO-1 in HBMECs.

Figure 5

(A) Time-dependent reduction of ZO-1 protein expression by morphine in HBMECs. (B) Treatment of cells with either the opioid receptor antagonist (naltrexone) or PDGF-BB neutralizing antibody results in inhibition of ZO-1 expression. All the data are presented as meanĀ±SD of at least three individual experiments. ***p<0.001 vs control group; ###p<0.001 vs morphine-treated group.