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. 2011 Jun 28;6(6):e21657. doi: 10.1371/journal.pone.0021657

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Siegmund et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. Intra- and intergland PWDs generally correlate. The trend line is based on three human CRCs, with the two MMR deficient cancers with much lower intragland PWDs. (circles are human CRCs, triangles are the clonal and polyclonal xenografts). B. Ratios of intra- to intergland PWDs were greater than 0.5 except for the MMR deficient CRCs, indicating much greater extinction within glands of the MMR deficient CRCs.