Table 2.
Multivariable models showing the hazard ratios for the associations between enrolment creatinine clearance and times to meeting criteria for initiation of cARTa
| Hazard ratios (95% confidence intervals) | ||
|---|---|---|
| Enrolment characteristic | Model 1 | Model 2b |
| Creatinine clearancec(mL/min) | ||
| ≥60 (reference) | 1.0 | 1.0 |
| < 60 | 1.34 (1.23-1.52)d | 1.24 (1.11-1.39)d |
| Age (per 10 year increase) | 1.00 (0.95-1.05) | 1.01 (0.96-1.07) |
| Male sex (compared with female sex) | 1.22 (1.09-1.37)e | 1.27 (1.13-1.42)d |
| WHO stage 2 (compared with stage 1) | 1.34 (1.22-1.48)d | 1.30 (1.18-1.43)d |
| CD4 cell count (per 50 cells/mm3 increase) |
0.88 (0.87-0.90)d | 0.88 (0.87-0.90)d |
| Haemoglobin (per 1 g/dL increase) | 0.90 (0.88-0.92)d | 0.91 (0.89-0.93)d |
| Weight (per 1 kg increase) | 0.99 (0.98-0.99)d | |
aCombination antiretroviral therapy, defined as development of either CD4 cell count < 200 cells/mm3 or WHO disease stage 3 or 4
bModel 1 adjusted for weight
cEstimated using the Cockcroft-Gault equation
dP < 0.0001
eP < 0.001