Table 4.

Multivariable models showing the hazard ratios for the associations between enrolment creatinine clearance and times to overall mortality

	Hazard ratios (95% confidence intervals)
Enrolment characteristic	Model 1	Model 2a
Creatinine clearanceb (mL/min)
≥60 (reference)	1.0	1.0
< 60	1.73 (1.19-2.51)c	1.25 (0.84-1.86)
Age (per 10 year increase)	1.22 (1.02-1.45)d	1.27 (1.07-1.51)c
Male sex (compared with female sex)	1.91 (1.29-2.81)e	2.40 (1.61-3.59)f
WHO stage 2 (compared with stage 1)	1.54 (1.09-2.18)c	1.37 (0.97-1.95)
CD4 cell count (per 50 cells/mm3 increase)	0.96 (0.91-1.01)	0.97 (0.91-1.02)
Haemoglobin (per 1 g/dL increase)	0.76 (0.72-0.81)f	0.78 (0.73-0.83)f
Initiation of antiretroviral therapy (compared with no initiation)	1.36 (0.91-2.02)	1.35 (0.90-2.01)
Weight (per 1 kg increase)		0.95 (0.93-0.97)f

^aModel 1 adjusted for weight

^bEstimated using the Cockcroft-Gault equation

^cP < 0.01

^dP < 0.05

^eP < 0.001

^fP < 0.0001WE