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Opsonized bacterial survival in U937 monocytic cell killing assays. (A) M1T1 GAS strain 5448 and isogenic ndoS knockout, 5448ΔndoS. (B) Exogenous pretreatment of plasma with rEndoS prior opsonization of GAS. (C) Heterologous expression of EndoS in NZ131 (serotype M49). Error bars indicate standard deviation from the mean. * indicates P < 0.05, ** indicates P < 0.01, *** indicates P < 0.001, ns indicates no significant difference.
