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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Hepatology. 2011 Jul;54(1):229–239. doi: 10.1002/hep.24368

Figure 5. Effects of Grp78 deletion on acute alcohol and HIV protease inhibitor-induced ER stress and liver injury.

Figure 5

Control, animals were gavaged with isocaloric liquid diet only; Treated, animals were gavaged with liquid diet containing alcohol and HIV protease inhibitors (HIV PIs), ritonavir and lopinavir with or without PBA. (A) Comparisons of ALT in WT versus LGKO. (B) Immunoblots of ER stress related transcription factors in nuclear protein extracts and ubiquitinated proteins in whole cell protein extracts. WTu, WT treated with Tunicamycin for 24 hours as positive control of ER stress response in vivo; (C) Comparison of 20S proteasome activities between WT and LGKO. Data are presented as RFU (relative fluorescent unit) recorded with a fluorometer. *p<0.05 and **p<0.01 compared to WT; #p<0.05 or ##p<0.01 compared to WT or LGKO with PBA, n= 5 mice.