Skip to main content
. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Hepatology. 2011 Jul;54(1):229–239. doi: 10.1002/hep.24368

Figure 6. Liver specific deletion of GRP78 exacerbates carbon tetrachloride (CCl4)-induced ER stress and liver fibrosis.

Figure 6

(A) Fibrotic/cirrhotic changes after treatment with CCl4. WT_C, WT injected with corn oil; WT_CCl4, WT injected with CCl4 mixed with corn oil (1:5); LGKO_C, knockout injected with corn oil; LGKO_CCl4, knockout injected with CCl4 mixed with corn oil (1:5); PBA, 4-phenylbutyrate. (B) Expression of collagen α1 analyzed with quantitative PCR. (C) Immunoblots of protein samples from mice with chronic CCl4 injection. (D) RT-PCR of mRNA of sXbp1, Derl3, Creld2, Gdf15 and Nupr1. *P<0.05 or **P<0.01 compared to WT without CCl4; #P<0.05 compared to PBA treatment; n=4.