Table 1.

Ten studies that used computer simulation models to compare computed tomographic colonography (CTC) and colonoscopy

Study	Model Type	Study Population & Time Horizon	De novo Cancers	Location	Multiple Adenomas	Malignant Potential
Heitman et al (29)	Decision tree	Canadian 50-year-old males to age 53 years	No	No	No	Adenoma Size: 6–9 mm vs.10+ mm
Sonnenberg et al (30)	Markov cohort	US 50-year-olds to death	No	No	No	Not Modeled
Ladabaum et alE (31)	Markov cohort	US 50-year-olds to death	Yes	No	No	Adenoma Size: <10 mm vs.10+ mm
Vijan et al (32)	Markov cohort	US 50-year-olds to death	No	No	No	Low Risk: 1–5 mm or 6–9 mm without high-risk histologyD High Risk: 10+ mm or <10 mm (1–5 mm or 6–9 mm) with high-risk histologyD
Hassan et alF (33)	Markov cohort	Italian 50-year-olds to age 80 years	Yes	No	No	Adenoma Size: 1–5 mm, 6–9 mm, 10+ mm
Lee et al (34)	Markov cohort	British 50-year-olds to death	No	YesA	YesC	Adenoma Size: 6–9 mm, 10+ mm
Telford et al (35)	Markov cohort	Canadian 50-year-olds to death	No	No	No	Low Risk: <9 mm without high-risk histologyD High Risk: 9+ mm or <9 mm with high-risk histologyD
Knudsen et al (7)
MISCANG	Microsimulation	US 65-year-olds to death	No	YesB	Yes	Adenoma Size: 1–5 mm, 6–9 mm, 10+ mm
CRC-SPIN	Microsimulation	US 65-year-olds to death	No	YesB	Yes	Adenoma Size: Continuous size in mm
SimCRC	Microsimulation	US 65-year-olds to death	No	YesB	Yes	Adenoma Size: 1–5 mm, 6–9 mm, 10+ mm

^ATwo locations modeled (distal colon and rectum versus proximal colon)

^BSix locations modeled: cecum; ascending, transverse, descending, and sigmoid colon; rectum

^COne adenoma may occur in each of two locations

^DHigh-risk histology is present when an adenoma has advanced dysplasia or villous features.

^EAdditional publication on CTC with this model: (50)

^FAdditional publications on CTC with this model: (51–55)

^GAdditional publication on CTC with this model:(56)