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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Hepatology. 2011 Jul;54(1):252–261. doi: 10.1002/hep.24339

Fig. 1.

Fig. 1

IL-22+ cells accumulate in the livers of patients with chronic HBV or HCV. (A) Immunohistochemical staining for IL-22 in normal healthy livers, HBV or HCV cirrhotic livers. Positive staining with IL-22 Ab is shown as a dark red color. IL-22+ immune cells are located mainly in inflammatory regions (upper panel: yellow arrows) but are also observed in sinusoids (lower panel: read arrows) from some patients. (B) The number of IL-22+ lymphocytes/per field (×100) correlates positively with the grade of inflammation. Each dot represents one patient. G: Grade of inflammation. **P<0.01; ***P<0.001 (C) Correlation between the number of IL-22+ cells/per field (×100) in the livers and serum ALT or AST from viral hepatitis patients.