Table I.
Upregulation of genes in the livers from IL-22TG vs WT mice
Gene title | UniGene ID | Gene symbol |
Fold change (IL-22TG vs WT) |
---|---|---|---|
Anti-oxidatant genes | |||
Metallothionein 1 | Mm.192991 | Mt1 | 20.4 |
Metallothionein 2 | Mm.147226 | Mt2 | 37.1 |
Mitogenic and proliferative genes | |||
Cyclin B1 | Mm.380027 | Ccnb1 | 1.5 |
Cyclin D1 | Mm.273049 | Ccnd1 | 1.8 |
Growth arrest specific gene 5 | Mm. 270065 | Gas5 | 1.5 |
Growth arrest specific gene 6 | Mm. 3982 | Gas6 | 1.6 |
Neuropilin 1 | Mm.271745 | Nrp1 | 2.4 |
Acute phase genes | |||
Serum amyloid A1 | Mm.148800 | Saa1 | 3.2 |
Serum amyloid A2 | Mm.200941 | Saa2 | 5.3 |
Serum amyloid A3 | Mm.14277 | Saa3 | 1.7 |
Serum amyloid A4 | Mm.3489 | Saa4 | 2.1 |
Serum amyloid P-component | Mm.330510 | Apcs | 2.5 |
Fibrinogen-like protein 1 | Mm.277955 | Fgl1 | 3.0 |
Orosomucoid 2 | Mm.14173 | Orm2 | 9.2 |
Orosomucoid 3 | Mm.381399 | Orm3 | 2.8 |
CD14 | Mm.3460 | Cd14 | 1.6 |
LPS binding protein | Mm.218846 | LBP | 2.0 |
Antimicrobial genes | |||
Lipocalin 2 | Mm. 9537 | Lcn2 | 25.1 |
Proteinase 3 | Mm. 2364 | Prtn3 | 7.4 |
Cytokine signaling –related genes | |||
Suppressor of cytokine signaling 3 | Mm.3468 | Socs3 | 4.0 |
Suppressor of cytokine signaling 2 | Mm.474283 | Socs2 | 2.8 |
Signal transducer and activator of transcription 3 | Mm.249934 | Stat3 | 1.6 |
Janus kinase 3 | Mm. 249645 | Jak3 | 1.6 |