(A) Wild-type and TNFR-DKO HSC proliferation. (B) LX2 proliferation after 24 hours of PDGF (20ng/ml) and/or TNF (50ng/ml) challenge. (C) Wild-type, TNFR-DKO, TNFR1-KO and TNFR2-KO proliferation after 24 hours of PDGF (20ng/ml) challenge. AKT phosphorylation induced by PDGF (10 or 20ng/ml) for 15 minutes in wild-type vs TNFR-DKO (D), TNFR1-KO (E), or TNFR2-KO (F) HSC. Data are mean±SD in A, C n=3 and *p≤0.05 vs. wild-type HSC; in B *p≤0.05 vs. PDGF untreated cells.