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(A) PDGF-β-receptor degradation after PDGF challenge (20ng/mL, 2 hours), and (B) JAK2 and ERK1/2 activation after PDGF challenge (15 minutes) in wild-type and TNFR-DKO HSC. (C) ERK1/2, AKT, and JAK2 activation by PDGF (20ng/ml) or TNF (50ng/ml) in LX2 cells. (D) p65 expression and AKT activation by PDGF (15 minutes) in Control and p65 siRNA transfected LX2 cells.
