Table 1.

Summary of subjects characteristics, broken down by diagnostic category Data presented as means (SD).

Variables	All	CN	MCI	AD	p
Number of subjects	208	96	67	45
Vascular risk score	0.29 (0.21)	0.25 (0.22)	0.24 (0.21)	0.29 (0.20)	0.51
Age, y	74.5 (7.9)	74.3 (7.5)	73.4 (7.2)	76.5 (9.6)	0.13
Years of Education, y	12.0 (5.1)	11.9 (5.1)	13.0 (5.3)	10.9 (4.4)	0.092
Gender (# male; % male)	84; 40.4	64; 66.7	35; 52.2	25; 55.5	0.15
WMH load (% TCV)	0.91 (1.09)	0.70 (0.85)	0.97 (0.91)	1.26 (1.60)	0.018*
Number of subjects with Apoe	171	78	54	39
ApoE Genotype (# ε4(-,-); % ε4(-,-))	115; 67.2	63; 80.8	33; 61.1	19; 48.7	0.016*

Chi-square tests were used for categorical variables and analysis of variance (ANOVA) for continuous variables. To normalize variance, WMH loads were log-transformed for ANOVA groups comparison.

Post hoc comparisons of significant group difference:

^*cognitively normal (CN) vs Alzheimer disease (AD)

MCI indicates mild cognitive impairments; WMH, White Matter Hyperintensities; TCV, Total Cranial Volume; WMH volumes were corrected for head size (% TCV).