. Author manuscript; available in PMC: 2012 Jul 1.

Published in final edited form as: Hepatology. 2011 Jul;54(1):173–184. doi: 10.1002/hep.24351

Table 3.

Hepatitis B virus as a Potential Risk factor for Cholangiocarcinoma

First author	Country	Study date	Risk factor	CC Type	Cases (% with risk factor)	Controls (% with risk factor)	Risk estimate (95% CI)	Selected adjusted variables
Shin¹⁷	Korea	1990–1993	HBsAg+	NS	41 (12.5%)	406 (3.5%)	1.3 (0.3–5.3)	Age, sex, socioeconomic status
Yamamoto⁵¹	Japan	1991–2002	HBsAg+	ICC	50 (4%)	205 (2%)	Not calculated	Age, sex
Shaib⁵³	US	1992–2002	HBsAg−/Anti-HBc+	ICC	83 (9.6%)	236 (0%)	28.6 (3.9–1268.1)	Age, sex, race
			HBsAg−/Anti-HBc+	ECC	163 (0%)	236 (0%)	3.2 (0.6–382)
Shaib⁴⁷	US	1993–1999	^{^} HBV	ICC	625 (0.2%)	90,834 (0.2%)	0.8 (0.1–5.9)	Age, sex, race, geographic location
Donato⁴²	Italy	1995–2000	HBsAg+	ICC	26 (11.5%)	824 (5.5%)	2.7 (0.4–18.5)	Age, sex, residence
Lee²⁷	Korea	2000–2004	HBsAg+	ICC	622 (13.5%)	2,488 (5.0%)	2.3 (1.6–3.3)	Age, sex
Zhou⁴¹	China	2004–2006	HbsAg+	ICC	312 (48.4%)	438 (9.6%)	8.9 (5.97–13.2)	Age, sex, date of admission

^{^}

Diagnostic code; HBsAg= Hepatitis B surface antigen; HBc= Hepatitis B core; HBV=Hepatitis B virus; CC = cholangiocarcinoma; NS= Not specified; ICC = intrahepatic cholangiocarcinoma; ECC = extrahepatic cholangiocarcinoma; CI = confidence interval