Eight week old c57BL/6 male mice were subjected to 10 days of 60% CR and then allowed to regain body weight. Mice (n=6/group) were then allowed to recover for one week and monitored for three days in metabolic cages. (A) Oxygen consumption, (B) carbon dioxide production, (C) body weight, (D) food intake, (E) locomotor activity, and (F) body composition were determined. Eight week old c57BL/6 mice received viral injections of either AAV-GFP or AAV-ΔFosB into the NAc. Four weeks later the mice were tested for (G) Oxygen consumption, (H) carbon dioxide production, (I) body weight, (J) food intake, (K) locomotor activity, and (L) body composition (*P<0.05, **P<0.01). Data are presented as mean ± SEM.