Table 1.
Characteristics of the samplesa
| Cohort | Total sample analyzed |
Gender (male) | Onset Age | Age-at-death | Disease Duration | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Percent | nb | Mean age |
Range | SD (±) |
n | Mean age |
range | SD (±) |
n | Mean duration (years) |
range | SD (±) |
n | ||
| PSP stage 1c | 1,114 | 55 | 599 | 68 | (41–93) | 8.2 | 827 | 75 | 45–99 | 8.0 | 1,070 | 7.4 | 1–21 | 3.2 | 827 |
| PSP stage 1 European Ancestry | 1,069 | 55 | 570 | 68 | (41–93) | 8.3 | 794 | 75 | 45–99 | 8.0 | 1,025 | 7.4 | 1–21 | 3.1 | 794 |
| PSP stage 2d | 1,051 | 53 | 530 | 65 | (40–91) | 7.3 | 913 | 75 | 57–94 | 7.4 | 118 | 8.0 | <1–18 | 3.3 | 42 |
a
Controls were young normal subjects recruited from the Children's Hospital of Philadelphia Health Care Network (See Online Methods for details). These were 3,287 controls for Stage 1 and 3,560 for Stage 2;
b
n, number of samples with available data. Values of n for each type of analysis do not add up to the total samples used because of missing values;
c
Stage 1 consisted of autopsy-confirmed cases.
d
The stage 2 dataset included 130 cases with autopsies. All stage 2 samples (cases and controls) were independent of stage 1 samples.