Table 1.
Characteristics of the subjects
| Subjects used in the evaluation of insulin secretion | Subjects used in the evaluation of insulin sensitivity | |||||||
|---|---|---|---|---|---|---|---|---|
| All | NGT | IGT | T2D | All | NGT | IGT | T2D | |
| n | 46 | 9 | 5 | 32 | 79 | 10 | 11 | 58 |
| Age (years old) | 50.4 ± 12.0 | 45.8 ± 14.3 | 46.4 ± 9.1 | 52.4 ± 11.5 | 53.1 ± 13.4 | 47.8 ± 15.0 | 49.7 ± 14.2 | 54.7 ± 12.9 |
| Sex (male/female) | 33/13 | 8/1 | 3/2 | 22/10 | 57/22 | 9/1 | 8/3 | 40/18 |
| BMI (kg m−2) | 26.2 ± 6.1 | 28.7 ± 8.6 | 26.0 ± 5.8 | 25.5 ± 5.3 | 25.6 ± 5.1 | 28.0 ± 8.4 | 26.3 ± 4.8 | 25.1 ± 4.3 |
| G (0) (mg dl−1) | 113.7 ± 25.1 | 83.9 ± 8.1 | 93.0 ± 13.9 | 125.4 ± 20.1 | 112.6 ± 21.6 | 84.4 ± 7.8 | 98.2 ± 13.8 | 120.1 ± 18.9 |
| G (30) (mg dl−1) | 205.7 ± 54.0 | 138.8 ± 29.8 | 179.6 ± 35.2 | 228.7 ± 43.5 | 202.9 ± 46.7 | 143.8 ± 32.3 | 188.0 ± 49.8 | 216.0 ± 39.5 |
| G (60) (mg dl−1) | 258.8 ± 78.0 | 157.2 ± 43.3 | 191.4 ± 21.1 | 297.9 ± 54.5 | 253.7 ± 64.8 | 157.5 ± 40.9 | 213.9 ± 35.8 | 277.8 ± 52.3 |
| G (120) (mg dl−1) | 254.8 ± 105.8 | 103.4 ± 19.0 | 154.2 ± 14.2 | 313.0 ± 65.9 | 254.4 ± 90.6 | 105.5 ± 19.0 | 162.1 ± 22.6 | 297.6 ± 60.4 |
| I (0) (μU ml−1) | 6.8 ± 6.6 | 11.5 ± 12.7 | 6.0 ± 2.5 | 5.7 ± 3.8 | 6.3 ± 5.8 | 10.7 ± 12.2 | 5.9 ± 4.3 | 5.6 ± 3.8 |
| I (30) (μU ml−1) | 35.1 ± 51.1 | 94.0 ± 89.6 | 35.5 ± 27.6 | 18.5 ± 17.9 | 28.7 ± 40.9 | 91.4 ± 84.9 | 29.5 ± 24.1 | 17.8 ± 15.5 |
| I (60) (μU ml−1) | 43.7 ± 50.5 | 110.0 ± 75.8 | 46.3 ± 23.3 | 24.7 ± 22.2 | 37.2 ± 41.1 | 104.2 ± 73.8 | 40.2 ± 24.4 | 25.1 ± 20.1 |
| I (120) (μU ml−1) | 44.0 ± 39.7 | 79.0 ± 61.9 | 56.3 ± 32.1 | 32.2 ± 25.3 | 41.1 ± 33.6 | 75.0 ± 59.7 | 44.2 ± 30.0 | 34.7 ± 24.1 |
| SSIHGC (μU ml−1) | 24.4 ± 24.8 | 56.4 ± 37.8 | 27.8 ± 9.0 | 14.9 ± 10.9 | ||||
| GIR/SSIHIC (mg kg−1 min−1 μU−1 ml) | 0.064 ± 0.034 | 0.074 ± 0.046 | 0.081 ± 0.032 | 0.059 ± 0.030 | 0.063 ± 0.032 | 0.072 ± 0.044 | 0.079 ± 0.037 | 0.059 ± 0.027 |
The G and I represent glucose and insulin concentrations during the OGTT, respectively. A subscript in parentheses represents a value at a time (min) after the oral glucose load. The SSIHGC and SSIHIC represent steady-state insulin concentrations during the HGC and the HIC, respectively. The GIR represents the steady-state glucose infusion rate during the HIC