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. 2011 Jun 27;5:10. doi: 10.3389/fncel.2011.00010

Figure 4.

Figure 4

Changes in paired-pulse ratio may contribute to the early increase in DDI. (A) Drawing of the recording configuration, in which GC release is evoked by extracellular stimulation in the EPL and IPSCs recorded in the MC. (B) Sample traces of responses to pairs of extracellular stimuli in the EPL with an interpulse interval of 100 ms. Traces are averages of 10, 8, and 11 trials, respectively. (C) Average paired-pulse ratio at different ages. At P3, the synapse displays paired-pulse facilitation, while at P15 and P30, it displays depression (N = 6 cells for each age). The P3 value is significantly different from the P15 and P30 values (the P3 value is significantly different from the P15 and P30 values, ANOVA p = 0.0039; pairwise Tukey’s p < 0.05 and 0.01, respectively).