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. 2011 Jun 27;5:10. doi: 10.3389/fncel.2011.00010

Figure 5.

Figure 5

Evoked DDI in 0 extracellular Mg peaks less sharply than in physiological Mg. (A) Sample single trace of DDI evoked by 100 ms voltage step from −70 to 0 mV, in two cells in P15 animals, one in physiological Mg (1.5 mM, blue), and one in 0 Mg (red). The period of the stimulus is blanked. (B) DDI plotted as a function of age for three conditions: 1.5 mM Mg and 100 ms step (blue); 0 Mg and 100 ms step (red), and 0 Mg and 5 ms step (purple). The 1.5-Mg: N = 7 cells for P3–6 and P9–12; N = 3 for P15 and P20; and N = 4 for P30. The 0-Mg, both step lengths: N = 8 for P3–6, N = 7 for P9–12, N = 4 for P15 and P20; and N = 3 for P30. At each age point the DDI in 0 Mg 100 ms step was significantly different from the DDI in 1.5 Mg (unpaired t-test, p < 0.02). Within the 0-Mg 100 ms step condition the DDI were significantly different with age, P15 being higher than P3–6 (ANOVA p = 0.04, Tukey’s p < 0.05). (C) DDI plotted as a function of age, normalized to the average value at P3 (dashed line drawn through ordinate value of 1)