FIG. 1.

The primary structure of peroxiredoxin 6 (Prdx6). (A) Deduced Prdx6 amino acid sequence for the mouse (M), rat (R), human (H), and bovine (B) proteins. The dots beneath the sequence indicate amino acids that are not fully conserved among the four species. The lipase and peroxidase motifs are indicated. Modified from Kim et al. (37) and Fisher et al. (21). (B) Phylogenetic tree for mammalian Prdxs constructed using ClustalW (1.7). Modified from Knoops et al. (41). (C) Consensus sequences aligned using ClustalW (1.7). The consensus sequences for the human, mouse, and rat homologs for Prdxs 1, 2, 3, 4, and 6 were generated using the consensus C program. The catalytic Cys residue is indicated by the arrow. The shading indicates regions of relatively high homology. Modified from Phelan (73).