Table 1.

Electrocardiogram parameters of control and MK-treated swine.

Condition	Group	HW/BW	RR (ms)	PQ (ms)	QRS (ms)	QT (ms)	QTc (ms)
PRE	CONT	n.a.	617 ± 41	97 ± 3	37 ± 1	325 ± 25	412 ± 19
	MKT	n.a.	649 ± 28	97 ± 2	39 ± 1	337 ± 17	417 ± 12
POST	CONT	n.a.	653 ± 30	102 ± 3	40 ± 2	338 ± 17	417 ± 11
	MKT	n.a.	580 ± 31	98 ± 4	38 ± 2	303 ± 15	398 ± 9
24 h	CONT	0.45 ± 0.02	542 ± 27#	96 ± 2	39 ± 1	278 ± 13	378 ± 8
	MKT	0.43 ± 0.01	560 ± 20#	98 ± 2	40 ± 1	293 ± 10	391 ± 7

Values are mean ± SEM. ECG data were obtained before I/R (PRE), 30 min of reperfusion (POST), and 24 h of reperfusion (24 h). CONT, control swine (n =8); MKT, midkine-treated swine (n =8); QTc = QT/(RR/1000)^1/2. Body weight (BW) measured at PRE was 40 ±1 kg for CONT, and 39 ± 1 kg for MKT (ns). Heart weight (HW) measured at 24 h was 178 ± 3 g for CONT, and 167 ± 3 g for MKT (ns). The differences between “CONT,” “POST,” and “24 h” within the CONT and MKT groups were tested by the paired Student’s t-test in such a way that each animal served as its own control (#p < 0.05 vs. PRE). The difference between the CONT and MKT groups at any moment was tested by ANOVA.