Fig. 1.

Dot- or dash-like cytoplasmic 43 kDa transactive responsive sequence DNA binding protein (TDP-43) pathology in a case of motor neuron disease (MND) clinically limited to lower motor neuron (LMN). Anti-TDP-43 immunohistochemistry using phosphorylation independent anti-TDP-43 antibodies in (a), i.e., commercial polyclonal anti-TDP-43, Proteintech Group Inc, as well as in (b), i.e., 171-anti-TDP-43, and the anti-phosphorylated S409/410 TDP-43 antibody in (c) showing dot-or dash-like inclusion formation in spinal cord lower motor neurons (examples denoted by arrows, bars 20 µm)