Fig. 2.

Lower and upper motor neuron 43 kDa transactive responsive sequence DNA binding protein (TDP-43) pathology in a patients with MND/LMN. Anti-TDP-43 immunohistochemistry using anti-phosphorylated S409/410 TDP-43 antibodies showing TDP-43 pathology (examples arrows) in the dorsal motor plate in the medulla oblongata (a) and motor cortex (b) (bars 100 µm). Since this antibody does not stain normal TDP-43, all of the immunoreactivity in brown reflects pathology