Fig. 3.

Cortical 43 kDa transactive responsive sequence DNA binding protein (TDP-43) pathology in a case of MND/LMN (same patient as in Fig. 1). Anti-TDP-43 immunohistochemistry using anti-phosphorylated S409/410 showing TDP-43 pathology (examples arrows) in the amygdala (a), dentate gyrus of the hippocampus (b), cingulate cortex (c), orbitofrontal cortex (d), and rarely visual cortex (e) (e.g., arrows) (bars 100 µm). As in Fig. 2, all of the immunoreactivity in brown here reflects pathology