OCTR-1 expressing neurons ASH and ASI suppress innate immunity by controlling the expression of pqn/abu genes. (A) Wild-type, octr-1(ok371) and FY746 octr-1(ok371);grEx158[Psra-6::octr-1] animals were exposed to P. aeruginosa. (B) Wild-type, octr-1(ok371) and FY745 octr-1(ok371);grEx157 [Poctr-1::octr-1::gfp] animals were exposed to P. aeruginosa. The survival graphs represent combined results of two independent experiments, N=90 adult animals per strain. (C) Quantitative reverse transcription-PCR analysis of abu-1, abu-12, abu-13, abu-14, and abu-15 expression in octr-1(ok371) and FY746 octr-1(ok371);grEx158[Psra-6::octr-1] relative to wild-type animals exposed to P. aeruginosa. N=3; bars represent mean ± SEM.