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. Author manuscript; available in PMC: 2011 Jun 29.
Published in final edited form as: Sci Signal. 2010 Jul 20;3(131):ra54. doi: 10.1126/scisignal.2000807

Fig. 3.

Fig. 3

Chronic alkaloid treatment increases μ–δ heteromer abundance. (A) CHO cells stably expressing μ and δ receptors were treated with the indicated ligands (1 μM) for 48 hours and μ–δ heteromer abundance was determined by ELISA. Results are means ± SEM (n=3–4 experiments). **p<0.01. μ–δ abundance refers to ELISA results with the μ–δ heteromer selective antibody (B) Morphine-treated (1 μM) SK-N-SH cells were probed by ELISA using monoclonal antibodies to μ, δ, or μ–δ receptors. Results are means ± SEM (n=3–4 experiments).