Table 1.
Clinical and pathological features of patients with HCCs.
| Patient number | Sex | Age (years) | Etiology | HCV genotype | Activity/Fibrosis* | Number of tumors | Size of largest tumor (cm) | Differentiation‡ | Gadd45β protein expressionΔ |
|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 50 | HCV | ND | A2/F4 | 2 | 6 | Pd | 0 |
| 2 | M | 48 | HCV | 3a | F4 | 5 | 3 | Md/Pd | 0 |
| 3 | M | 67 | HCV | ND | F4 | 7 | 2 | Pd | 0 |
| 4 | M | 51 | HCV | 3a | F4 | 2 | 6 | Pd | 0 |
| 5 | M | 75 | HCV+alcohol | 1b | A2/F3 | 1 | 3 | Md | + |
| 6 | F | 71 | HCV | 1b | A1/F1 | 1 | 12 | Wd | + |
| 7 | M | 69 | HCV+alcohol | 2a | A1/F2 | 1 | 3 | Pd | 0 |
| 8 | M | 61 | HBV | NA | A1/F1 | 1 | 4 | Md | +++ |
| 9 | M | 57 | HBV | NA | A1/F2 | 2 | 3 | Pd | ++ |
| 10 | M | 45 | HBV | NA | A2/F2 | 1 | 13 | Md | ++ |
| 11 | M | 60 | HBV | NA | A1/F3 | 1 | 3 | Pd | ++ |
| 12 | M | 50 | HBV | NA | F3/F4 | 2 | 3 | Md | +++ |
| 13 | M | 78 | ND | NA | A0/F3 | 10 | 6 | Md | +++ |
| 14 | M | 73 | alcohol | NA | A1/F2 | 6 | 13 | Pd | +++ |
| 15 | M | 71 | alcohol | NA | F1 | 1 | 7 | Pd | + |
| 16 | M | 67 | alcohol | NA | F1 | 1 | 10 | Md | +++ |
| 17 | M | 33 | ND | NA | ND | 1 | 10 | Wd | +++ |
HCV: hepatitis C virus; HBV: hepatitis B virus; ND: not determined; NA: not applicable
*
According to Metavir scoring: A = activity: absent (A0); mild (A1); moderate (A2); severe (A3); F = fibrosis: absent (F0); mild (F1), moderate (F2), severe (F3); cirrhosis (F4)
‡
According to Edmonson grade: Wd (well-differentiated); Md (moderately differentiated); Pd (poorly differentiated)
Δ
Gadd45β protein expression in tumoral tissues as determined by densitometric analysis of immunoblots. Scores: 0 = no expression; + = weak expression; ++ = moderate expression; +++ = strong expression.