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. 2011 Feb 22;2(4):185–197. doi: 10.1021/cn100111a

Table 1. Summary of the Properties of the Widely Used or Recently Developed Caged Glu Probesa.

caged Glu ε (λmax) ϕ (%Glu yield) εϕ 2P evoked voltage |rise time (ms) pharmacology toward GABA-A stability in aqueous buffer solubility (mM) at pH 7.4 in aqueous buffer
CNB137 500 (350) 0.14 (100) 60 no 2P current partial agonist half-life 17 h RT >50
MNI86,87 4300 (330) 0.085 (>95) 357 3.5 strong antagonist at 10 mM stable 1400
RuBi135 5600 (450) 0.13 (NQ) 728 14 50% inhibition at 0.3 mM stable NR
PMNB138 9900 (317) 0.1 (100) 990 NR NR stable requires 1% DMSO
antMNI134 27000 (300) 0.085 (94) 2295 NR NR stable 33
BNSF133 64000 (415) 0.25 (65) 16000 NR NR NR 0.1
CDNI130 6400 (330) 0.6 (100) 3840 NR mild antagonist at 0.4 mM stable pH 2 100
a

Abbreviations and symbols: 2P, two-photon; NQ, not quantified but probably high; NR, not reported; ε, extinction coefficient (M−1 cm−1); λmax, wavelength maximum of absorption (nm); ϕ, quantum yield of photolysis.