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. Author manuscript; available in PMC: 2011 Jun 29.
Published in final edited form as: Nat Genet. 2009 Jul 26;41(8):941–945. doi: 10.1038/ng.409

Figure 5.

Figure 5

Schematic representation of the dynamic exchange of factors at a transcriptionally active TSS or other regulatory elements.

These sites can be occupied transiently by H3/H2A-containing NCPs (blue circle), by H3.3/H2A.Z NCPs (pink circle), by transcription factors (TFs, yellow oval), or they can be free of proteins. The mechanisms of exchange among these different states are not clear. Each of these states will be detected by the assay method designed for that purpose, but over time each site will occupy all four states.