Table 1.
Comparison of different software tools for secondary metabolite biosynthesis analysis
| Software | Open-source & stand-alone available | Covers full tree of life | NRPS/PKS detection | NRPS/PKS detailed functional domain annotation | NRP/PK core structure prediction | Detection of other biosynthetic classes | Gene cluster border prediction | Comparative gene cluster analysis | Prediction of all secondary metabolite-like genomic regions |
|---|---|---|---|---|---|---|---|---|---|
| ClustScan | + | + | + | + | ± | ||||
| CLUSEAN | + | + | + | ||||||
| NP.searcher | + | + | + | + | |||||
| SBSPKS | + | + | + | ||||||
| SMURF | + | ± | + | ||||||
| antiSMASH | + | + | + | + | + | + | + | + | + |
Comparison of functionalities of currently existing programs or software packages for secondary metabolite biosynthesis analysis.