Table 2.

Main genes affected by KdpDE

Gene function and identifier	Gene product	Fold change, mutant vs WTc
Metabolism genes
SAOUHSC_01389	Thioredoxin reductase	2
SAOUHSC_00113	AdhE product = alcohol-acetaldehyde dehydrogenase	2
SAOUHSC_01619	Probable exodeoxyribonuclease VII small subunit	2.14
SAOUHSC_01825	Aminotransferase, class V	2
SAOUHSC_02281	IlvD product = dihydroxy-acid dehydratase	2.63
SAOUHSC_02282	IlvB product = acetolactate synthase large subunit	2.14
SAOUHSC_02283	Similar to acetolactate synthase small subunit	2.63
SAOUHSC_02671	NarK product = nitrite extrusion protein	2
SAOUHSC_02679	Similar to nitrate reductase delta chain	3.73
SAOUHSC_02680	NarH product = nitrate reductase beta chain	3.03
SAOUHSC_02682	NasF product = uroporphyrin III C-methyltransferase	2.29
SAOUHSC_02684	NasD product = nitrite reductase	2
SAOUHSC_02849	Pyruvate oxidase	2.14
SAOUHSC_02945	Precorrin-2 dehydrogenase	2
SAOUHSC_02969	ArcA product = arginine deiminase	2.46
SAOUHSC_03011	HisB product = imidazole glycerolphosphate dehydratase	2.14
SAOUHSC_03012	Hypothetical protein	2.29
SAOUHSC_03013	Histidinol dehydrogenase	2
SAOUHSC_01030	Putative NrdH-redoxin	2
SAOUHSC_00465	Veg product = VEG protein homolog	2.29
SAOUHSC_00898	ArgH product = argininosuccinate lyase	2.63
SAOUHSC_00899	ArgG product = argininosuccinate synthase	2.46
SAOUHSC_02118	Glutamyl-tRNAGln amidotransferase subunit C	2.29
SAOUHSC_01191	RpmB product = 50S ribosomal protein L28	0.47
SAOUHSC_01216	SucC product = succinyl-CoAa synthetase subunit beta	0.5
SAOUHSC_01218	SucD product = succinyl-CoA synthetase alpha subunit	0.5
SAOUHSC_00195	Acetyl-CoA acetyltransferase homolog	0.5
SAOUHSC_00196	Putative 3-hydroxyacyl-CoA dehydrogenase FadB	0.47
SAOUHSC_00197	Putative acyl-CoA dehydrogenase FadD	0.5
SAOUHSC_00198	Putative acyl-CoA synthetase FadE	0.44
SAOUHSC_00199	Putative acetyl-CoA/acetoacetyl-CoA transferase	0.47
SAOUHSC_00206	LctE product = l-lactate dehydrogenase	0.44
SAOUHSC_00365	AhpC product = alkyl hydroperoxide reductase subunit C	0.5
SAOUHSC_01002	Quinol oxidase polypeptide II QoxA	0.5
SAOUHSC_02366	FbaA product = fructose-bisphosphate aldolase	0.5
Cell surface protein genes
SAOUHSC_01385	PstB product = phosphate ABC transporter	3.24
SAOUHSC_01386	Similar to phosphate ABC transporter	2.63
SAOUHSC_02311	KdpB product = probable potassium-transporting ATPase B	2
SAOUHSC_02310	KdpC product = probable potassium-transporting ATPase C	2.14
SAOUHSC_01990	Glutamate ABC transporter ATP-binding protein	4
SAOUHSC_00636	Similar to ABC transporter, permease protein	2.14
SAOUHSC_00637	Similar to ABC transporter ATP-binding protein	2.14
SAOUHSC_02661	ScrA product = PTSb system, sucrose-specific IIBC component	0.43
Regulator genes
SAOUHSC_01384	Similar to negative regulator PhoU	2.46
SAOUHSC_01490	Hu product = DNA-binding protein II	0.44
SAOUHSC_02314	KdpD product = sensor protein	0.0059
SAOUHSC_02261	Accessory gene regulator protein B	0.5
SAOUHSC_02264	Accessory gene regulator protein C	0.5
SAOUHSC_02262	Accessory gene regulator protein D	0.41
SAOUHSC_02810	Transcriptional regulator, MerR family	0.44
SAOUHSC_00794	GapR product = glycolytic operon regulator	0.35
Virulence genes
SAOUHSC_02629	Similar to multidrug resistance protein	2
SAOUHSC_02851	LrgA family protein	2
SAOUHSC_02855	Similar to secretory antigen precursor SsaA	2.63
SAOUHSC_02971	Aur product = zinc metalloproteinase aureolysin	2.29
SAOUHSC_00069	Spa product = immunoglobulin G binding protein A precursor	0.31
SAOUHSC_00114	CapA	0.38
SAOUHSC_00115	CapB	0.35
SAOUHSC_00116	CapC	0.35
SAOUHSC_00117	CapD	0.38
SAOUHSC_00118	CapE	0.44
SAOUHSC_00119	CapF	0.41
SAOUHSC_00120	CapG	0.44
SAOUHSC_00121	CapH	0.35
SAOUHSC_00122	CapI	0.43
SAOUHSC_00123	CapJ	0.43
SAOUHSC_00124	CapK	0.46
SAOUHSC_00125	CapL	0.5
SAOUHSC_00126	CapM	0.5
SAOUHSC_00127	CapN	0.5
SAOUHSC_00300	Geh product = glycerol ester hydrolase	0.41
SAOUHSC_02260	Hld product = delta-hemolysin	0.38
SAOUHSC_02709	HlgC product = gamma-hemolysin component C	0.47
SAOUHSC_02710	HlgB product = gamma-hemolysin component B	0.41
Hypothetical protein genes
SAOUHSC_02384	Hypothetical protein	2
SAOUHSC_02523	Hypothetical protein	2
SAOUHSC_02858	Hypothetical protein	2
SAOUHSC_01296	Hypothetical protein	2.46
SAOUHSC_01729	Hypothetical protein	2.14
SAOUHSC_01991	Hypothetical protein	2.82
SAOUHSC_00202	Hypothetical protein	2
SAOUHSC_02850	Hypothetical protein	2
SAOUHSC_03047	Hypothetical protein	2
SAOUHSC_01032	Hypothetical protein	2.14
SAOUHSC_01072	Hypothetical protein	2.14
SAOUHSC_00704	Hypothetical protein	2.29
SAOUHSC_02886	Hypothetical protein	2.29
SAOUHSC_01557	Hypothetical protein	0.38
SAOUHSC_02521	Hypothetical protein	0.5
SAOUHSC_02838	Hypothetical protein	0.38
SAOUHSC_00091	Hypothetical protein	0.5
SAOUHSC_00094	Hypothetical protein	0.44
SAOUHSC_01675	Hypothetical protein	0.5
SAOUHSC_01918	Hypothetical protein	0.5
SAOUHSC_02781	Hypothetical protein	0.47
SAOUHSC_02788	Hypothetical protein	0.33
SAOUHSC_02805	Hypothetical protein	0.36
SAOUHSC_00401	Hypothetical protein	0.5
SAOUHSC_00413	Hypothetical protein	0.47
SAOUHSC_01956	Hypothetical protein	0.47
SAOUHSC_00414	Hypothetical protein	0.47
SAOUHSC_00257	Hypothetical protein	0.5
SAOUHSC_01109	Hypothetical protein	0.47
SAOUHSC_01956	Hypothetical protein	0.47
SAOUHSC_02796	Hypothetical protein	0.088

^aCoA, coenzyme A.

^bPTS, phosphotransferase system.

^cWT, wild type.