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The MTR transporter contributes to β-defensin resistance in H. ducreyi. (A to C) Survival of 35000HP(pLSSK), 35000HPmtrC(pLSSK), and 35000HPmtrC(pmtrC) exposed to the indicated concentrations of HBD-2 (A), HBD-3 (B), and HBD-4 (C). (D) Survival of 35000HP, 35000HPΔcpxA, and 35000HPΔcpxR exposed to HBD-3. The data represent the means and standard errors of at least three independent assays. The asterisks indicate significant differences from the parent strain (P < 0.05).
