Table 3.
Effects of deleting mtrC or cpxA on H. ducreyi resistance to α-defensins
| Strain | % Survival with peptidea: |
||
|---|---|---|---|
| HNP-1 | HNP-2 | HD-5 | |
| 35000HP(pLSSK) | 91.8 ± 6.4 | 90.8 ± 0.9 | 100.4 ± 3.2 |
| 35000HPmtrC(pLSSK) | 100.0 ± 8.0 | 74.0 ± 1.6b | 87.7 ± 2.4b |
| 35000HPmtrC(pmtrC) | 101.6 ± 5.9 | 93.0 ± 1.5 | 99.7 ± 2.8 |
| 35000HPΔcpxA | 97.3 ± 3.9 | 104.4 ± 5.6 | ND |
a
Percent survival when exposed to 20 μg/ml of the indicated peptide compared to control well with no AP. The data represent the means ± standard errors of at least three independent assays. ND, not determined.
b
Significant difference from 35000HP (P ≤ 0.05).