Fig. 2.

Opsonization targets Francisella to different phagocytic receptors. BMMs from either C57BL/6, MR-KO, SRA-KO, CD11b-KO, or FcRγ-KO mice were infected with either unopsonized (A), serum-opsonized (B), or IgG-opsonized (C) Schu S4, as described in Materials and Methods, and intracellular CFU were enumerated at 1 h p.i. Results are expressed as percentages of phagocytic uptake in control C57BL/6 BMMs and are the means ± standard deviations of three to six independent experiments. Asterisks denote statistically significant differences in phagocytic uptake compared to control BMMs, according to a one-way analysis of variance followed by a Dunnett posttest (P < 0.05).