Fig. 2.
Skin lesions formed by S. pyogenes in Crl:SKH1-Hrhr mice. (A) Mice were infected subcutaneously with 2 × 107 bacteria, and resulting lesions were measured daily for 2 weeks (“*” indicates P < 0.05 using the Mann-Whitney test). The plot shows median, quartiles, minimum, and maximum. Clear boxes represent wild-type-infected mice (n = 15), and gray boxes represent spyA mutant-infected mice (n = 13). (B) CFU per gram of lesion tissue were determined at 24, 48, and 72 h postinfection in mice infected with 8 × 106 bacteria. No significant differences were detected using a two-tailed, unpaired Student t test after confirming equal variance by F test. Each circle represents a single mouse. Open circles represent wild-type CFU, and filled circles represent spyA CFU.