Fig. 3.

Absence of MyD88 signaling increases mortality rates and tissue fungal burdens. (A) Survival times of MyD88^−/− (n = 9) and WT (n = 10) mice after i.t. infection with 1 × 10⁶ P. brasiliensis yeast cells was determined in a period of 70 days. The results are representative of two independent experiments. *, P < 0.05. (B and C) Recovery of fungal loads (CFU) from organs of MyD88^−/− and WT mice. The bars represent mean ± SEM log₁₀ numbers of CFU obtained from groups of 6 to 8 mice at 48 h (B) and 8 weeks (C) after infection. Levels of NO (μM) present in tissue homogenates obtained 48 h (D) and 8 weeks (E) after fungal infection. The results are representative of three experiments with equivalent results. *, P < 0.05.