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Induction of P450 3A4 mRNA levels in OS187 and COL cells by etoposide (–), doxorubicin (–), and ifosfamide (–). P450 3A4 mRNA expression levels were determined by quantitative reverse-transcriptase polymerase chain reaction (RT-PCR). The values represent the average of triplicates standardized to GAPDH expression and are represented relative to untreated controls for each cell line. (–) represents control untreated cells.
